A Milford resident, Melillo has served as the assistant superintendent of curriculum and instruction for Hamden Public Schools since July 2012. During that time he also served as interim superintendent of schools, from February to July 2014. He served as Hamden’s director of elementary education, October 2010-June 2012; principal at Shepherd Glen School, also in Hamden, July 2007-October 2010; and as assistant principal at ACES-Thomas Edison Middle School in Meriden, August 2005-June 2007. He began his career as a fifth to sixth grade teacher at Church Street School and Bear Path School in Hamden, August 1993-June 2005. Melillo earned his Bachelor of Science degree in Education at the University of Connecticut, graduating in May 1991.